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The Great Events by Famous Historians [Volumes 1-14]

Электронная книга - «The Great Events by Famous Historians [Volumes 1-14]». Краткое содержание книги:

Антология содержит:
The Great Events by Famous Historians, Volume 01
The Great Events by Famous Historians, Volume 02 / (From the Rise of Greece to the Christian Era)
The Great Events by Famous Historians, Volume 03
The Great Events by Famous Historians, Volume 04
The Great Events by Famous Historians, Volume 05 / (From Charlemagne to Frederick Barbarossa)
The Great Events by Famous Historians, Volume 06 / (From Barbarossa to Dante)
The Great Events by Famous Historians, Volume 07
The Great Events by Famous Historians, Volume 08 / The Later Renaissance: from Gutenberg to the Reformation
The Great Events by Famous Historians, Volume 09
The Great Events by Famous Historians, Volume 10
The Great Events by Famous Historians, Volume 11
The Great Events by Famous Historians, Volume 12
The Great Events by Famous Historians, Volume 13
The Great Events by Famous Historians, Volume 14
The Great Events by Famous Historians, Volume 17
The Great Events by Famous Historians, Volume 21 / The Recent Days (1910-1914)
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"I have intrusted a most important matter to you, which I firmly believe will prove of essential benefit to the human race. I know you, and should not wish what I have stated to be brought into conversation; for should anything untoward turn up in my experiments I should be made, particularly by my medical brethren, the subject of ridicule—for I am the mark they all shoot at."

Jenner's reasons for concealment did not arise from any selfish or unworthy motive. The publicity he had always given to the subject and the efforts he had made among his professional associates to pursue the inquiry exclude the possibility of entertaining such a suspicion. It arose from a dread of disappointment and the fear of failure should the matter be brought forward in a state other than that of a maturity sufficient to carry conviction immediately upon its promulgation. In the course of his researches he was led to conclude that swinepox, as well as cowpox, was only a variety of smallpox. He inoculated his eldest son with the matter of swinepox and produced a disease similar to a very mild smallpox. After this, the inoculation of variolous matter would produce no effect.

He ascertained that cowpox, as it was commonly termed by the milkers, would frequently fail in effecting a security against the smallpox. This led him to inquire more particularly into the variety of spontaneous eruptions to which the teats of the cow were liable, and to discriminate the different kinds of sores produced by them on the hands of the milkers, and to establish the character of those which possessed a specific power over the constitution, and those which had no such efficacy. He found that instances occurred in which the true cowpox failed in preventing smallpox; but nothing daunted by this apparently fatal discovery he set about ascertaining the causes of this deviation. He found the specific virtues of the virus to have been lost or deteriorated so that it was rendered capable only of producing a local affection and had no influence whatever upon the constitution; and by the greatest ingenuity and patience of observation of the analogies drawn from the virus of smallpox, aided by his knowledge of the laws of the animal economy, he discovered that it was only in a certain state of the vesicle that the virus was capable of affording its protecting agency, and that when taken under other conditions, or at other periods, it could produce a local disease, yet that it was not able to manifest any constitutional effect, or afford immunity from the invasions of the smallpox.

On May 14, 1796, Jenner inserted lymph taken from the hand of Sarah Nelmes who was infected with cowpox, into the arm of James Phipps, a healthy boy about eight years of age. This is the first instance of regular inoculation of the vaccine disease by Jenner. The boy went through the disorder, and on July 1st following he had the matter of smallpox introduced into his arm, but no effect followed. Jenner had not before seen the cowpox but as presented on the hands of the milkers, nor had it been transmitted from one human being to another. He was struck with its great resemblance to the smallpox pustule. The success of this case must necessarily have operated powerfully upon him, and have urged him to continue the research with increased energy.

His anticipations thus realized, his intentions accomplished, what must have been the feelings of such a man as Jenner? They were suited to the magnitude of the occasion, and mark the character of the philosopher, distinguished as it ever was by great simplicity, benevolence, and humility. "While," says he, "the vaccine discovery was progressive, the joy I felt at the prospect before me of being the instrument destined to take away from the world one of its greatest calamities, blended with the fond hope of enjoying independence and domestic peace and happiness, was often so excessive, that in pursuing my favorite subject among the meadows I have sometimes found myself in a kind of reverie. It is pleasant to me to recollect that these reflections always ended in devout acknowledgments to that Being from whom this and all other mercies flow." Lord Bacon said that "it is Heaven upon earth to have a man's mind move in charity, rest in Providence, and turn upon the poles of truth." Jenner was a striking illustration of the truth of that remark.

The modesty of Jenner was evidenced in his original intention of submitting his observations on the cowpox in a paper addressed to the Royal Society. Doctor Baron tells us that "when the subject was laid before the president (the late Sir Joseph Banks), Jenner was given to understand that he should be cautious and prudent; that he had already gained some credit by his communications to the Royal Society and ought not to risk his reputation by presenting to the learned body anything which appeared so much at variance with established knowledge, and withal so incredible." It came forth most unostentatiously, about the end of June, 1798, dedicated to his friend Doctor Parry of Bath. Doctor Jenner visited London in the month of April of that year, and remained until July 14th. His object in this visit was to demonstrate the disease to his professional friends, but such was the distrust, or apathy, felt on the occasion, that Jenner returned to the country, without having been able to prevail on a single individual to submit to the inoculation of the virus.

The virus Jenner brought to London was consigned to the care of the late Mr. Cline, of St. Thomas's Hospital. This celebrated surgeon inserted some of it, by two punctures, into the hip of a young patient with a disease of that part of the body. This calescent mode of proceeding was adopted with the idea of exciting a counter-irritation in the diseased part. The intention was to convert the vesicles into an issue, after the progress of the cowpox had been observed. This idea was, however, abandoned. Smallpox matter was afterward inserted into this child in three places. It produced a slight inflammation on the third day, and then subsided. The child was effectually protected against the disease. Mr. Cline now became very sanguine as to the result and inoculated three other children with lymph taken from the vesicles of the child, but no evil effect ensued. The subject began to excite the attention of the profession, and all were eager to put the matter to the test of experiment. Mr. Cline urged Doctor Jenner to settle in London. He promised him ten thousand pounds a year as the result of his practice. What was his reply?

"Shall I, who even in the morning of my days, sought the lowly and sequestered paths of life, the valley, and not the mountain; shall I, now my evening is fast approaching, hold myself up as an object for fortune and for fame? Admitting it as a certainty that I obtain both, what stock should I add to my little fund of happiness? My fortune, with what flows in from my profession, is sufficient to gratify my wishes; indeed, so limited is my ambition, and that of my nearest connections, that even were I precluded from future practice I should be enabled to satisfy all my wants. As for fame, what is it? A gilded butt, forever pierced with the arrows of malignancy."

That a discovery of such importance to mankind, once divulged, should bring forth many claimants, and that its author should be subjected to virulent attacks, is easy to be conceived. Jenner, however, never thought it necessary to reply to unfounded and harsh aspersions, satisfied in the strength of his own case, and feeling the justice and truth of his own claims and position. The practice being now established, it is unnecessary even to refer to the names of the opponents of vaccination. Many mistakes, and some of a serious nature, occurred to interrupt the progress of the discovery; these had been for the most part foreseen by Jenner, and were satisfactorily explained. In a letter to a friend, Jenner says, "I will just drop a hint. The vaccine disease, in my opinion, is not a preventive of the smallpox, but the smallpox itself; that is to say, the horrible form under which the disease appears in its contagious state is, as I conceive, a malignant variety." Again: "What I have said on this vaccine subject is true. If properly conducted, it secures the constitution as much as variolous inoculation possibly can. It is the smallpox in a purer form than that which has been current among us for twelve centuries past." And, in a letter to Mr. Pruen, "I have ever considered the variola and the vaccine radically and essentially the same. As the inoculation of the former has been known to fail, in instances so numerous, it would be very extraordinary if the latter should always be exempt from failure. It would tend to invalidate my early doctrine on this point."

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